You could get drowsy or dizzy. Do not drive, use machinery, or do something that wants mental alertness until you know the way this medication affects you.
The respiratory depression requires a reduction in the responsiveness in the Mind stem respiratory centers to the two raises in carbon dioxide rigidity and to electrical stimulation.
The codeine and promethazine in Promethazine HCl and Codeine Phosphate Oral Answer may possibly boost the frequency of seizures in clients with seizure Problems, and should boost the possibility of seizures occurring in other scientific settings related to seizures.
The narcotic antagonist, naloxone hydrochloride, might be administered when substantial respiratory depression occurs with promethazine and codeine; any depressant consequences of promethazine are usually not reversed with naloxone. Diazepam might be employed to regulate convulsions. Keep away from analeptics, which may lead to convulsions. Acidosis and electrolyte losses need to be corrected. A rise in temperature or pulmonary troubles may possibly signal the necessity for institution of antibiotic therapy.
Be sure you know the way to choose this item and what other drugs you'll want to keep away from using with it. See also Drug Interactions segment. Get health-related help right away if any of such really severe Unwanted side effects manifest: slow/shallow breathing, unconventional lightheadedness, intense drowsiness/dizziness, difficulty waking up.
Lactation At least 1 death was documented in a very nursing infant who was subjected to higher levels of morphine in breast milk because the mother was an extremely-quick metabolizer of codeine.
In case you are prescribed this medication on a daily agenda and miss a dose, get it the moment you don't forget. Whether it is close to the time of the following dose, skip the skipped dose. Just take your following dose in the normal time. Tend not to double the dose to capture up.
The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are intricate, necessitating watchful thing to consider of the results about the dad or mum drug, codeine, and the active metabolite, morphine.
Thing to consider need to be supplied to your discontinuation of promethazine HCl also to using other medicine if these reactions manifest. Respiratory despair, nightmares, delirium, and agitated actions have also been documented in Many of these individuals.
It truly is soluble in drinking water and freely soluble in Alcoholic beverages. It has a molecular bodyweight of 320.88, a molecular components of C17H20N2S•HCI, and the subsequent structural method:
This is especially essential for aged patients, who could be extra delicate to the results of discomfort medicines. If far too much of the drugs is taken for a long period, it could turn into habit-forming (producing psychological or physical dependence) or bring about an overdose.
Codeine is adjusted into a robust opioid drug (morphine) in One's body. In a lot of people, this transformation comes about more rapidly and even more completely than common, which boosts the threat of very really Promethazine codeine syrup serious Unintended effects.
When utilized for an extended time, this medication might not perform as well and will demand distinct dosing. Talk to your physician if this medication stops Performing perfectly.
If someone has overdosed and has serious signs and symptoms including passing out or problems breathing, get in touch with 911. Otherwise, contact a poison Command Middle straight away.